Thursday, October 31, 2013

LeAnn Rimes' invasion of privacy suit dismissed




FILE - In this July 1, 2013 file photo, Leann Rimes performs at the Friend Movement Anti-Bullying Benefit Concert at the El Rey Theatre, in Los Angeles. Los Angeles court records show a judge on Monday, Oct. 28, 2013, dismissed an invasion of privacy lawsuit filed by Rimes against two women she claimed illegally recorded a phone conversation with her and posted it online. (Photo by John Shearer/Invision/AP, file)






LOS ANGELES (AP) — An invasion of privacy lawsuit that LeAnn Rimes filed against two Northern California women has been dismissed.

Los Angeles court records show the actress-singer's suit against Kimberly Smiley and her daughter Alexis Smiley was dismissed Monday. The dismissal prevents Rimes from re-filing the case.

Rimes sued the women in August 2012 claiming they recorded a phone conversation with her and posted it online. She said the recording damaged her reputation and relationships, and caused her emotional distress.

Kimberly Smiley denied wrongdoing in an interview after the suit was filed.

Steve White, an attorney representing the Smileys, says the two sides resolved their differences and he could not comment further.

Rimes' lawyer, Larry Stein, was not immediately available to comment.

Source: http://news.yahoo.com/leann-rimes-invasion-privacy-suit-dismissed-211430198.html
Category: george zimmerman   elvis presley   Hyperloop  

President & the Democrats Lied Us Into a Bad Law


Greg Sargent thinks it’s unseemly and ill-mannered for Republicans to focus on the fact that a great many people are losing their health insurance because of Obamacare. He does make a few very reluctant concessions. For instance:



Critics of the law are right to ask whether it is having an adverse impact on these millions of Americans. And the White House could have been clearer in laying the groundwork for this political argument: It wasn’t sufficient to say people who like their plans will be able to keep it, which is narrowly untrue.


But this is just the necessary back swing required for teeing up the real wrongdoers here, the Republicans.





Source: http://www.realclearpolitics.com/2013/10/30/president_amp_the_democrats_lied_us_into_a_bad_law_318855.html
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A sauropod walks into a bar. 'Why the long neck?'

A sauropod walks into a bar. 'Why the long neck?'


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PLOS ONE introduces a new Collection on Sauropod Gigantism




A new PLOS Collection featuring research on the complex evolutionary cascade theory that made the unique gigantism of sauropod dinosaurs possible launched on October 30th. This Collection features new research articles that have published in the open access journal PLOS ONE.


Sauropod dinosaurs were the largest terrestrial animals to roam the Earth, exceeding all other land-dwelling vertebrates in both mean and maximal body size. While convergently evolving many features seen in large terrestrial mammals, such as upright, columnar limbs and barrel-shaped trunks, sauropods evolved some unique features, such as the extremely long necks and diminutive heads they are famous for.


The unique gigantism of sauropod dinosaurs has long been recognized as an important problem in the evolution of vertebrates, raising questions as to why no other land-based lineage has ever reached this size, how these dinosaurs functioned as living animals, and how they were able to maintain stable populations over distinct geological periods.


This new PLOS Collection discusses major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals, and to explain their evolutionary success and uniquely gigantic body size.


The articles address these questions from a number of varied disciplinary viewpoints, including those of ecology, engineering, functional morphology, animal nutrition, and palaeontology. For instance, one section features articles from researchers that investigated sauropod mobility and posture, to better understand the reasons for their extremely long necks.

"You could explain gigantism just by looking at the trait of having many small offspring. But our model shows us there were probably several factors," says Dr. P. Martin Sander, a professor at the Steinmann Institute for Geology, Mineralogy and Palaeontology at the University of Bonn, Germany.


###

PLEASE LINK TO THE SCIENTIFIC ARTICLE IN ONLINE VERSIONS OF YOUR REPORT (URL goes live after the embargo ends): http://www.ploscollections.org/sauropodgigantism


Disclaimer: This press release refers to upcoming articles in PLOS ONE. The releases have been provided by the article authors and/or journal staff. Any opinions expressed in these are the personal views of the contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.


About PLOS ONE: PLOS ONE is the first journal of primary research from all areas of science to employ a combination of peer review and post-publication rating and commenting, to maximize the impact of every report it publishes. PLOS ONE is published by the Public Library of Science (PLOS), the open-access publisher whose goal is to make the world's scientific and medical literature a public resource.


All works published in PLOS ONE are Open Access. Everything is immediately availableto read, download, redistribute, include in databases and otherwise usewithout cost to anyone, anywhere, subject only to the condition that the original authors and source are properly attributed. For more information about PLOS ONE relevant to journalists, bloggers and press officers, including details of our press release process and our embargo policy, see the EveryONE blog at http://everyone.plos.org/media.




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A sauropod walks into a bar. 'Why the long neck?'


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

30-Oct-2013



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Contact: Jennifer Horsley
collections@plos.org
44-012-234-42836
Public Library of Science



PLOS ONE introduces a new Collection on Sauropod Gigantism




A new PLOS Collection featuring research on the complex evolutionary cascade theory that made the unique gigantism of sauropod dinosaurs possible launched on October 30th. This Collection features new research articles that have published in the open access journal PLOS ONE.


Sauropod dinosaurs were the largest terrestrial animals to roam the Earth, exceeding all other land-dwelling vertebrates in both mean and maximal body size. While convergently evolving many features seen in large terrestrial mammals, such as upright, columnar limbs and barrel-shaped trunks, sauropods evolved some unique features, such as the extremely long necks and diminutive heads they are famous for.


The unique gigantism of sauropod dinosaurs has long been recognized as an important problem in the evolution of vertebrates, raising questions as to why no other land-based lineage has ever reached this size, how these dinosaurs functioned as living animals, and how they were able to maintain stable populations over distinct geological periods.


This new PLOS Collection discusses major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals, and to explain their evolutionary success and uniquely gigantic body size.


The articles address these questions from a number of varied disciplinary viewpoints, including those of ecology, engineering, functional morphology, animal nutrition, and palaeontology. For instance, one section features articles from researchers that investigated sauropod mobility and posture, to better understand the reasons for their extremely long necks.

"You could explain gigantism just by looking at the trait of having many small offspring. But our model shows us there were probably several factors," says Dr. P. Martin Sander, a professor at the Steinmann Institute for Geology, Mineralogy and Palaeontology at the University of Bonn, Germany.


###

PLEASE LINK TO THE SCIENTIFIC ARTICLE IN ONLINE VERSIONS OF YOUR REPORT (URL goes live after the embargo ends): http://www.ploscollections.org/sauropodgigantism


Disclaimer: This press release refers to upcoming articles in PLOS ONE. The releases have been provided by the article authors and/or journal staff. Any opinions expressed in these are the personal views of the contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.


About PLOS ONE: PLOS ONE is the first journal of primary research from all areas of science to employ a combination of peer review and post-publication rating and commenting, to maximize the impact of every report it publishes. PLOS ONE is published by the Public Library of Science (PLOS), the open-access publisher whose goal is to make the world's scientific and medical literature a public resource.


All works published in PLOS ONE are Open Access. Everything is immediately availableto read, download, redistribute, include in databases and otherwise usewithout cost to anyone, anywhere, subject only to the condition that the original authors and source are properly attributed. For more information about PLOS ONE relevant to journalists, bloggers and press officers, including details of our press release process and our embargo policy, see the EveryONE blog at http://everyone.plos.org/media.




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Source: http://www.eurekalert.org/pub_releases/2013-10/plos-asw102913.php
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Will GPS Cannon Spell The End Of High-Speed Chases?


Police cars in Iowa and Florida are testing a secret weapon: a small cannon embedded in the grill. It shoots "tracking" bullets — containing tiny GPS devices — that can stick to the trunk of a suspect's car. Police could then follow a suspect at a leisurely pace instead of embarking on a dangerous high-speed chase.



Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


RENEE MONTAGNE, HOST:


Good morning. I'm Renee Montagne. Police cars in Iowa and Florida are testing a secret weapon: a small cannon embedded in the grille. It shoots tracking bullets containing tiny GPS devices that can stick to the trunk of a suspect's car. Police could then follow a suspect at a leisurely pace instead of embarking on a dangerous high-speed chase. The weapon, very James Bond, except American police would need to get a warrant before attaching a GPS to a car. It's MORNING EDITION.


Copyright © 2013 NPR. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to NPR. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.


NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.


Source: http://www.npr.org/2013/10/30/241787233/will-gps-cannon-spell-the-end-of-high-speed-chases?ft=1&f=3
Tags: chicago marathon   Cassidy Wolf   will smith   Jana Lutteropp   Dick Van Dyke  

More power to you: Marines boost energy, lighten load

More power to you: Marines boost energy, lighten load


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Office of Naval Research





ARLINGTON, Va.In an effort to move toward increased energy independence in the field, Marines used a wearable solar-powered system to extend the battery life of crucial electronic devices during a recent field exercise, officials announced Oct. 30.


Sponsored by the Office of Naval Research (ONR) and assembled at the Naval Surface Warfare Center Dahlgren Division, the Marine Austere Patrolling System (MAPS) combines solar power and an individual water purifier to help lighten the load of Marines conducting lengthy missions in remote locations with few or no options for resupply.


"The primary challenge facing the Marine Corps in expeditionary environments is that we're carrying too much weight," said Capt. Frank Furman, logistics program manager for ONR's Expeditionary Maneuver Warfare and Combating Terrorism Department.


MAPS gives individuals the ability to manage power and filter water on the move. A key features is a flexible solar panel, about the size of a piece of paper, made possible by breakthroughs at the Naval Research Laboratory.


The new gear proved to be a go-to power source to keep radio communications up and running during a field test with the 1st Battalion 5th Marines at the Mountain Warfare Training Center in Bridgeport, Calif. While in a remote mountainous area, company and platoon commanders had to rely on Marines using the MAPS gear because their radios were the only ones that still had power.


"As engineers, we rely heavily on Marine feedback to improve system function, form and fit," said Justin Miller, MAPS lead systems integrator. "Actually observing Marines use the system in this challenging terrain to sustain their gear is very positive, because we can incorporate their feedback into the design."


Marines use more electronic devices than ever before, including radios, night-vision goggles and GPS systems. Each comes with its own set of batteries and spares, which can add several pounds to what a Marine has to carry.


"Marines planning a 24-hour mission may need four batteries, but we bring eight as a safety factor, because we can never risk running out completely," said Furman, an infantry officer who served in two tours to Afghanistan. "MAPS provides two benefits. First, we can lessen the risk of batteries running out completely. Second, the weight of spare batteries and extra water is eliminated. This directly affects on our endurance and ability to move and stay alert."


For a 96-hour patrol, MAPS has the potential to reduce the weight of batteries and water carried by a Marine from more than 60 pounds to 13 pounds. The system's ability to sustain Marines for longer stretches reduces the need for dangerous logistics resupply operations, a goal stated in the Marine Corps Expeditionary Energy Strategy and Implementation Plan.


This month's field evaluation followed on the heels of a similar evaluation in July by members of the 3rd Battalion 1st Marines at Camp Pendleton, Calif.


The Marine Corps Expeditionary Energy Office continues to work with partner agencies to collect data from exercises and inform future development and fielding of subcomponent systems.

###


ONR provides the science and technology necessary to maintain the Navy and Marine Corps' technological advantage. Through its affiliates, ONR is a leader in science and technology with engagement in 50 states, 70 countries, 1,035 institutions of higher learning and 914 industry partners. ONR employs approximately 1,400 people, comprising uniformed, civilian and contract personnel, with additional employees at the Naval Research Lab in Washington, D.C.




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More power to you: Marines boost energy, lighten load


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PUBLIC RELEASE DATE:

30-Oct-2013



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Contact: Peter Vietti
onrpublicaffairs@navy.mil
703-696-5031
Office of Naval Research





ARLINGTON, Va.In an effort to move toward increased energy independence in the field, Marines used a wearable solar-powered system to extend the battery life of crucial electronic devices during a recent field exercise, officials announced Oct. 30.


Sponsored by the Office of Naval Research (ONR) and assembled at the Naval Surface Warfare Center Dahlgren Division, the Marine Austere Patrolling System (MAPS) combines solar power and an individual water purifier to help lighten the load of Marines conducting lengthy missions in remote locations with few or no options for resupply.


"The primary challenge facing the Marine Corps in expeditionary environments is that we're carrying too much weight," said Capt. Frank Furman, logistics program manager for ONR's Expeditionary Maneuver Warfare and Combating Terrorism Department.


MAPS gives individuals the ability to manage power and filter water on the move. A key features is a flexible solar panel, about the size of a piece of paper, made possible by breakthroughs at the Naval Research Laboratory.


The new gear proved to be a go-to power source to keep radio communications up and running during a field test with the 1st Battalion 5th Marines at the Mountain Warfare Training Center in Bridgeport, Calif. While in a remote mountainous area, company and platoon commanders had to rely on Marines using the MAPS gear because their radios were the only ones that still had power.


"As engineers, we rely heavily on Marine feedback to improve system function, form and fit," said Justin Miller, MAPS lead systems integrator. "Actually observing Marines use the system in this challenging terrain to sustain their gear is very positive, because we can incorporate their feedback into the design."


Marines use more electronic devices than ever before, including radios, night-vision goggles and GPS systems. Each comes with its own set of batteries and spares, which can add several pounds to what a Marine has to carry.


"Marines planning a 24-hour mission may need four batteries, but we bring eight as a safety factor, because we can never risk running out completely," said Furman, an infantry officer who served in two tours to Afghanistan. "MAPS provides two benefits. First, we can lessen the risk of batteries running out completely. Second, the weight of spare batteries and extra water is eliminated. This directly affects on our endurance and ability to move and stay alert."


For a 96-hour patrol, MAPS has the potential to reduce the weight of batteries and water carried by a Marine from more than 60 pounds to 13 pounds. The system's ability to sustain Marines for longer stretches reduces the need for dangerous logistics resupply operations, a goal stated in the Marine Corps Expeditionary Energy Strategy and Implementation Plan.


This month's field evaluation followed on the heels of a similar evaluation in July by members of the 3rd Battalion 1st Marines at Camp Pendleton, Calif.


The Marine Corps Expeditionary Energy Office continues to work with partner agencies to collect data from exercises and inform future development and fielding of subcomponent systems.

###


ONR provides the science and technology necessary to maintain the Navy and Marine Corps' technological advantage. Through its affiliates, ONR is a leader in science and technology with engagement in 50 states, 70 countries, 1,035 institutions of higher learning and 914 industry partners. ONR employs approximately 1,400 people, comprising uniformed, civilian and contract personnel, with additional employees at the Naval Research Lab in Washington, D.C.




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Source: http://www.eurekalert.org/pub_releases/2013-10/oonr-mpt103013.php
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Apple's tablet lead shrinks as Android gains momentum






Apple’s once-dominant lead in the fast-growing tablet market is shrinking as buyers move to Android tablets, which are cheaper and available in different sizes, according to separate research released by IHS and IDC on Wednesday.


Tablet shipments during the third quarter this year totaled 47.6 million units, growing by 36.7 percent compared to the same quarter last year, according to IDC. Android tablets drove the growth, while Apple’s iPad shipments were flat and Windows tablets continued to struggle.


Apple maintained the top spot in tablet shipments, totaling 14.1 million iPads during the quarter, growing by just 0.6 percent compared to the previous year. The company’s tablet market share fell to 29.6 percent during the third quarter, down from 40.2 percent a year ago.


The current tablet market share of 29.6 percent is Apple’s lowest to date, IDC said. Research firm IHS pegged Apple’s third-quarter market share at 29.7 percent.


Apple’s tablet shipments slowed due to a delay in product launches to the fourth quarter from earlier in the year. But the company is poised to regain market share with the new iPad Air and iPad Mini with Retina display, which will start shipping in November.


“With two 7.9-inch [iPad Mini] models starting at $299 and $399, and two 9.7-inch models starting at $399 and $499, Apple is taking steps to appeal to multiple segments,” said Jitesh Ubrani, IDC research analyst, in a statement.


Who else is selling tablets?


Samsung was the biggest beneficiary of the growth in Android tablets, holding 20.4 percent market share during the third quarter, up from 12.4 percent a year ago. The South Korean company’s tablet shipments totaled 9.7 million units, growing by 123 percent compared to last year.


Asustek was in third place with shipments up 53.9 percent to 3.5 million. Lenovo was in the fourth spot, with tablet shipments of 2.3 million, growing by a whopping 420.7 percent. Acer was in fifth place, with quarterly shipments growing by 346.3 percent.


While Apple is the solo tablet vendor with iOS, the sheer volume and spate of sub-$250 tablets has made Android a leading tablet OS, said Rhoda Alexander, director of tablet research at IHS.


“The erosion in Apple’s unit shipment market share was inevitable,” Alexander said in a statement.


Samsung took some cues from its smartphone market and expanded its tablet offerings at different prices, Alexander said. But the low margins of Android devices have hurt the profits of tablet makers.


“Cheaper almost always wins the volume race, and competitors were quick to adjust pricing when it became clear that it was impossible to achieve anything close to Apple’s unit growth at the same price level,” Alexander said.


Android assisted by small tablet vendors


The overall installed base of Android tablets received an assist from a group of “other” small tablet vendors, which held the single largest market share in the IDC and IHS surveys. The group includes regional tablet vendors in China that ship sub-$100 tablets with 7-inch screens, cheap components, and older versions of Android. Tablet shipments from that group totaled 16.8 million units according to IDC, and 16.4 million according to IHS.


The return rates on those cheap tablets are high, and the devices don’t last too long. The cheap-tablet business model is not yet proven, analysts said.


“Shipments alone won’t guarantee long-term success. For that you need a sustainable hardware business model, a healthy ecosystem for developers, and happy end users,” said Tom Mainelli, research director of tablets at IDC.








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Source: http://www.techhive.com/article/2059660/apples-tablet-lead-shrinks-as-android-gains-momentum.html#tk.rss_all
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The creepiest photographs of things you can only see under a microscope

The creepiest photographs of things you can only see under a microscope

Nikon just announced the winners for its 2013 Small World Photomicrography Competition. It's basically a collection of the best images of things you can only see under a light microscope. Or better yet, it's the best photographs of things you can't actually see. Here are some fantastically creepy shots that were our favorites.

Read more...


    






Source: http://feeds.gawker.com/~r/gizmodo/full/~3/pMZrkFmT0XM/@caseychan
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Teachers Share Their Top Safety Concerns


Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


MICHEL MARTIN, HOST:


I'm Michel Martin and this is TELL ME MORE from NPR News. Later in the program, we'll head into the Beauty Shop, where our panel of women commentators and journalists take on some hot topics of the week, including adult Halloween costume dilemmas. And we'll ask if Jay-Z has another problem to add to his 99 - we promise we'll explain all that.


But first, we want to turn to a much more serious topic and that is the recent spate of violence that we've seen in some schools around the country. Students at Sparks Middle School in Nevada returned to school this week. That's after a 12-year-old fatally shot a teacher, wounded two classmates, and then turned the gun on himself. That boy has now been identified, finally, as Jose Reyes. That was traumatic in and of itself, but then another teacher was stabbed to death last week in Massachusetts. Authorities there have charged a 14-year-old student with her death. Now these tragedies are - or should be - disturbing to everybody, but they hit especially close to home for educators.


So we've gathered a group of educators from different parts of the country and we wanted to check in with them to ask how they respond to these recent events. If they are prepared for them professionally, personally and emotionally. So we're joined now by Lisa Davenport, she's an eighth grade English teacher with the Washington, D.C. public schools. Welcome. Thank you so much for joining us.


LISA DAVENPORT: Thank you for inviting me.


MARTIN: Also joining us is Barrett Taylor, he's an assistant principal with the St. Louis public schools in Missouri. Thank you so much for joining us once again.


BARRETT TAYLOR: Thank you for having me on the show.


MARTIN: And Allison Pratt is a kindergarten teacher in the school district of Onalaska, which is in Wisconsin. Allison Pratt, thank you so much for joining us also.


ALLISON PRATT: You're welcome. Thank you for this opportunity.


MARTIN: Now I just wanted to briefly ask each of you, when stories like that hit the news, I have to be honest, I think of my children's teachers, so I wanted to ask if you think of yourselves. Do you think about yourself? Lisa?


DAVENPORT: I think, for me, as soon as I hear those stories I immediately think of my child who's in the seventh grade, and I wonder about her safety at her school and I think about, you know, what kind of procedures do they have in place? If they have anything in place at all, and think about the atmosphere as far as the culture at the school - meaning, how are the kids able - how are they relating to one another? Is there a lot of bullying going on? Are they more compassionate with one another? And I think that's one of the main reasons why I chose the school that I chose for her.


MARTIN: That's interesting. So you think about your daughter, you don't think about yourself? You think about your kids, not yourself first. That's interesting. Barrett Taylor, what about you?


TAYLOR: When I hear these issues, I sort of think about school safety in general, and I think about - that schools are not, necessarily, not any safer. I really focus on the clients that we, as educators, are serving, and I think about how they are constantly changing. I think with schools - I think schools, like everything else in the country, are evolving and we as educators must be more cognizant of our surroundings while in and outside of the workplace to make sure that schools are safe.


MARTIN: OK. Allison, what about you?


PRATT: My first thought goes to the children in my classroom and what the protocols are in my school district for school safety. It is just natural for educators to not think about themselves, but, because we're giving to others, to think about people around us.


MARTIN: I think that's an important thing for people to hear. So, you know, that I think everybody remembers the Sandy Hook Elementary School shootings, which happened last year. You know, since that terrible incident, there have been over a dozen additional school shootings. And I wanted to ask each of you if you think your job has become more dangerous over the time that you've been doing it. So, Barret Taylor, I'll start with you on this. Do you think it's become more dangerous being a teacher?


TAYLOR: I don't think it's necessarily becoming more dangerous. I think, unfortunately, the students that we are serving are a little different than they were, you know, 20 or 30 years ago. I think somebody said something about, you know, bullying. When I think about bullying, when I was a kid, bullying happened. But the difference between bullying today and 20 years ago is that bullying does not stop when you go home. It takes place on the social media. Things like Facebook and Twitter. So with the advent of social media, it's really changed the educational landscape.


MARTIN: Allison, what do you think? Do you think it's become more dangerous, being a teacher?


PRATT: It has changed. I have been in this field for 30 years, and families, children, communities, society certainly is different than it was in the early '80s when I began. The schools are required, or asked, to deal with more issues that children face in and out of school. And I think that safety may depend on the place in the country that you are located. It's important that schools have in place crisis plans. It's been a priority in Wisconsin, and in 2009, Wisconsin Act 309 required schools to develop a comprehensive school safety bill. So there are procedures in place and they are reviewed frequently.


MARTIN: I want to hear more about that from you - from you, Allison, in a minute. But, Lisa, what about you? I mean, do you think teaching has changed, do you feel it's more dangerous since you got into the field?


DAVENPORT: Well, when I first started out, I started out in the inner-city, and, to be quite honest, I just think that - I think that as far as students coming in and taking their frustration and anger out on a larger - you know, on a larger population, that part has changed in my opinion. I started out in the early '90s. I think violence has always been there, but it's been more of a one-on-one thing, and it's definitely changed since I was, you know, in school myself. If you were bullied or someone bothered you, usually you would go get your cousin, someone of their - of the same size, same age, in order to handle whatever the problem was and then it was over. But like the gentleman said, it definitely goes beyond. It doesn't just end in school - in the school or in the schoolyard. It goes beyond that with the social media, and that's becoming a big, big problem I think.


MARTIN: Could you talk a little bit more about that? You're saying it kind of follows these kids at home. They can't leave it at school or - it's never over. Is that...


DAVENPORT: Because they're basically belittling, degrading, mocking one another in the media, on Facebook, Instagram, and I forget - I'm not sure about all those other types of social medias out there. But they - it goes way beyond that. And I think that communication is going back and forth and it just keeps things going as opposed to just ending it. And I think we're in a society, in my opinion, where our students - they're dealing with issues on a greater level, and I feel that they need - a lot of them don't have the coping skills...


TAYLOR: Agreed.


DAVENPORT: ...To deal with the problems that they're facing. I think that has changed, definitely, since I was, you know, in school. But I think them being able to cope with their problems is a huge problem as well.


MARTIN: I can totally see your point on that, particularly I'm thinking about mobile phones, because when I was growing up - and maybe when you were growing up - our parents controlled the phones. So they decided who we spoke to at home at night, you know. They answered the phone, and if they didn't want you to speak to whoever was there, you weren't - you were not talking to that person. And whereas now, kids often, particularly as they get older, tend to have their own phones, and so they control their interactions with people unless their parents take them - take them away. So I can see your point on that. So, Barrett Taylor, you were saying - you were agreeing with Lisa Davenport. You're saying that a lot of kids don't have the emotional resources to handle some of the things that are thrown at them. You want to talk a little bit more about that?


TAYLOR: With the shootings that happen in school and the shootings sometimes that happen in the workplace, the one - in some of the cases, the one common denominator that seems to be coming up is these individuals have mental health issues. And, from my vantage point, it seems like mental health issues, and diagnosing those issues, and getting those people services seems to be the elephant in the room, because I think we really need to be more aggressive about if someone needs help, getting them help before it gets to a situation where they come in and do something that can potentially harm innocent individuals.


MARTIN: But haven't people, Barrett Taylor, always had mental health problems if we think about it? I mean, the fact that we have language for it now and maybe a greater understanding and ability to diagnose things or to understand what they are, maybe has - what's changed. So what's changed in the school environment? You just think that kids are more willing to act out, or what do you think? Or people are less willing to intervene? What do you think has changed now?


TAYLOR: And this is more outside of the school, but I was thinking about, you know, I used to play video games when I was younger and I always had parents who would talk to me about what was going on in these games, and it seems like the kids today have more access to these violent video games where they're going and, you know, they're online and they're shooting and killing people. And kids really do not understand what death is, and so, I just wonder sometimes, how does - what's the correlation between violent video games and kids committing acts of mass violence, such as school shootings.


MARTIN: Well, that's one of those topics people fight a lot about in academics, and intellectuals and people who research this question fight a lot about it. I don't think we can resolve it here. But so - what I would like to ask each of you - and if you're just joining us, we're talking about school safety with a roundtable of educators. We're joined by Barrett Taylor, that's who was speaking just now. He's an assistant principal in the St. Louis public school district. Allison Pratt's also with us, she's a kindergarten teacher with a school district of Onalaska in Wisconsin. And Lisa Davenport is with us. She's an eighth grade English teacher with the D.C. public schools. I just want to mention, they're all here on their own time because they all wanted to talk about this. I just feel that that's important to note. So, Allison, I think you wanted to say something.


PRATT: Yes, I would like to address the topic of self-worth and how children feel about themselves. I think it needs to be talked about in this mental health issue and where their worth comes from. Self-worth should come from within, and all of the video games, and material goods, and everything that children have access to is making their worth come from outside of themselves. And so they don't have the social emotional health that they need, and they don't know how to deal with the feelings that they have. And it becomes aggressive. Many of these violent people who have gone into schools don't care. That is their worth - that is their last hurrah. They're going to go out in, may I say, a blaze of glory, and if we address where that worth is coming from and that social emotional health in a different way, I think this will change.


MARTIN: I wanted to ask in the time that we have left - and we have about six minutes left - I'd love to hear from each of you about this. What do you think would help you, as educators, to address these issues? I mean, you've all made the point that - it's interesting to me that all of you, when I started asking about you, you all talk about your kids. You all talk about the kids first. So what would help you help them? Do you think you have what you need, Lisa?


DAVENPORT: No, I do not think that I have what I need. I think more training in dealing with mental health, how to address it, identify it - I think that definitely will help me as a regular educator. I'm not familiar with a lot of the, you know, mental health issues and how to identify it. Of course, teaching for a while, you can - after, you know, working with students, you can pretty much tell, you know, what's wrong, as far as if they have an academic type problem or a learning disability, I should say. As far as mental health, sometimes you can even determine that, depending on the child, but I would love to have more training as far as how to deal with my students with emotional and mental problems. And being able to have those resources in the building on a regular basis. I think that would definitely help.


MARTIN: Allison, what do you think?


PRATT: I feel equipped. As I mentioned before, Wisconsin is on top of this issue. I believe it's a priority here through passage of laws requiring us to develop comprehensive school safety bills, bullying policies, and being awarded a four-year federal grant on safe and supportive schools looking at those conditions. Having our Department of Public Instruction involved to have programs and also my union. My union is on top of this, also, providing assistance to schools and communities to help them avert crisis, providing...


MARTIN: So you feel you've got the training.


PRATT: I do.


MARTIN: You feel like the training is there and you've got access to it. That's...


PRATT: Yes, inside and outside of my school with our crisis team and the protocols in place, thank you.


MARTIN: Barrett Taylor?


TAYLOR: I do feel equipped. My district has provided me with the tools to be successful, but the one thing that I, as a teacher and now as an assistant principal - that I feel like I constantly want is more parental involvement. I get a lot a kids who come in who do not have mentors in their lives, they do not have, you know, a mother or father in their lives. Their grandmothers might be raising them, and they need more structure in their lives. And it makes me think about when I used to be a kid. Every day I got home, my dad would ask me what did I learn, how was my school day, and when I talk to some of these kids, they don't have those pieces in their lives. So going back to what someone else alluded to or said was, this whole thing about self-worth, you know, really developing and building these kids up so they can be strong individuals at school and they can be successful in the academic environment. It's important to me.


MARTIN: Is this fixable? Is the kind of we're talking about fixable? I mean, I'm mindful of the fact that these terrible and traumatic - and these incidents in the news could be isolated. I mean, it could be something that just, you know, it happens. It's terrible, we get through it, and it's not really indicative of any larger trend. But I hear all of you talking about the fact that you're worried about some of the mental and emotional health of some if your kids, and some of you feel you've got the resources to deal with it - the society. Some of you don't. Do you think this is fixable, Lisa? Do you think that we could get back together a year from now - two, five - and say, you know what, we're good, we don't have to worry about this again. We don't have to worry about another Sandy Hook? What do you think?


DAVENPORT: I don't think it's something that can be done overnight. This is definitely something I've thought about for a while. Definitely, when we hear these incidents, like the gentleman said, I really feel like parents - we need more parental involvement, most definitely, to help build the self-worth of our students. That's where it comes from first, in my opinion. I believe that we can make progress, as far as it being something that we will never hear of again as far as the violence in schools. I'm not sure if we could - we could minimize it, but I don't think we could do away with it altogether.


MARTIN: And do you feel - is that a pessimistic attitude, or you just think it's just realistic? Are you sad when you say that, or...


DAVENPORT: I'm sad when I say that. I don't feel - I hope I'm not being pessimistic. I think I'm being more realistic about the situation, because like, you know, they say, it takes a village to raise a child. And I just feel that, you know, in the environment that I work in, we have separate groups trying to help that child, but that main piece - parents - that's what we need.


MARTIN: Well, I just want to take the couple of seconds that we have left to thank you all very much for your very important work. If no one else says thank you today, let me be the one to thank you today. Thank you all.


PRATT: Thank you.


TAYLOR: Thank you.


MARTIN: Lisa Davenport is an eighth-grade English teacher with the D.C. public schools, here with us in our Washington, D.C. studios. Barrett Taylor is an assistant principal at a middle school in St. Louis, Missouri, joining us from St. Louis Public Radio. Allison Pratt is a kindergarten teacher with the Onalaska school district in Wisconsin, with us from Wisconsin Public Radio in La Crosse. Thank you all so much for your time today.


PRATT: Thank you.


DAVENPORT: You're welcome.


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Kristin Cavallari, Jay Cutler expecting 2nd baby

FILE - This April 12, 2012 file photo shows Kristin Cavallari at the Conde Nast Traveler Hot List Party at The Presidential Suite of Hotel Bel-Air in Los Angeles. Cavallari and her Chicago Bears quarterback husband Jay Cutler are expecting their second baby. The 26-year-old former star of MTV’s “Laguna Beach” and “The Hills” confirmed the news Wednesday, Oct. 30, 2013, on Twitter. The couple have a 14-month-old son and were married last June in Nashville, Tenn. (AP Photo/Danny Moloshok, File)







FILE - This April 12, 2012 file photo shows Kristin Cavallari at the Conde Nast Traveler Hot List Party at The Presidential Suite of Hotel Bel-Air in Los Angeles. Cavallari and her Chicago Bears quarterback husband Jay Cutler are expecting their second baby. The 26-year-old former star of MTV’s “Laguna Beach” and “The Hills” confirmed the news Wednesday, Oct. 30, 2013, on Twitter. The couple have a 14-month-old son and were married last June in Nashville, Tenn. (AP Photo/Danny Moloshok, File)







NEW YORK (AP) — Kristin Cavallari and her Chicago Bears quarterback husband Jay Cutler are one step closer to having their own football team.

Cavallari is pregnant with their second baby. The 26-year-old former star of MTV's "Laguna Beach" and "The Hills" confirmed the news Wednesday on Twitter. She wrote: "We are so excited for Camden to be a big brother!"

Camden is the couple's 14-month-old son.

Cavallari and Cutler were married last June in Nashville, Tenn.

The family splits their time between Nashville and Chicago.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-10-30-People-Kristin%20Cavallari/id-e79ccd56c8dc4f8a82ebdab5261bfe88
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Wednesday, October 30, 2013

What Obama Really Meant


Way, way back before time itself began, President Barack Obama said these words, in reference to the Affordable Care Act: "If you like your plan, you can keep it." And then, as Daily Intel's Dan Amira pointed out Tuesday, he said it a bunch more times!






Source: http://www.realclearpolitics.com/2013/10/30/what_obama_really_meant_318901.html
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Massive ads set to take over Windows' Bing app






Unwary users searching for Hertz, Jaguar, or Radio Shack while using the latest version of Windows may be in for a rude shock: the appearance of ads that can take over nearly your entire screen.


So far, the large ads are only accessible via the “smart search” within Windows 8.1. Typing “baseball,” for example, on the Windows Start page launches the Bing app, where images of baseballs are intermixed with the official Major League Baseball site, the relevant Wikipedia article, and relevant videos.


Type in “hertz,” however, and a customized “hero ad” will nearly fill your screen, offering links for Gold Plus rewards members, online rservations, and special offers, as well as links to actually reserve a rental car. And if you happened to be searching for hertz, the international unit of frequency, you’ll have to scroll horizontally to the third result on the right. It’s a marked change from the old Bing app, where eight separate results are visible on the first page, and the Web, where Bing’s results are organized vertically.


Bing hero HertzBing’s “smart search” Hertz ad.

Microsoft began introducing ads into Bing smart searches this past summer, when smaller ads began appearing next to search results. Meanwhile, Windows 8.1 began introducing hero-sized index pages of its own, so that searches for “Prince” or “Lady Gaga,” for example, returned pages with biographical information and links to songs.


Searches for generic terms like “baseball” still seem safe, but beware wandering on the Web in search of brands.


“The goal of Hero ads is to enable searchers to quickly find the most relevant information and complete the most popular tasks for the brand they are specifically searching for via a beautiful visual and interactive experience created in partnership with our brand partners,” wrote Stephen Sirich, the general manager of Microsoft’s Online Division at Microsoft, in a blog post.


Bing Search for hertz, Windows 8A search for “Hertz” using the Bing search app under Windows 8.0.

Similar ads have been created for Land Rover, Jaguar, Home Depot, Norwegian Cruise Line, Radio Shack, Hertz, Volkswagen, and a “few additional popular brands,” Sirich added. “We will continue to solicit feedback from both users and marketers during this pilot and will use those learnings to create an experience that works best for advertisers and Windows 8.1 users.”


Microsoft’s online business has consistently lost money, so the new ads will probably fill the hole where traditional banner advertising or other display ads would appear. But if more and more advertisers sign on, you’ll likely wade through a number of similar splash screens before ending up on actual, useful search results.


Fortunately, there’s an workaround: if you don’t like them, don’t click the ads. They’ll eventualy go away.








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Cisco to release free standard software to boost Web videoconferencing





Web videoconferencing may get easier after a decision by Cisco Systems that should help bring widely used technology into browsers.


Cisco announced in a blog post Wednesday that it plans to make its codec based on the H.264 standard available as a free, open-source download from the Internet. Also on Wednesday, Mozilla said it would add the technology to Firefox.


H.264 is a standard for real-time video that is widely used by Cisco and other vendors. It hasn't become a native part of the major browsers because it requires royalty payments to MPEG LA, which licenses the technology. In order to make H.264 available for browsers, Cisco will not pass on its licensing costs for the codec.


Without a native codec in browsers that works with major videoconferencing platforms, users have had to download an application or plug-in before doing a video chat in a browser, said Nemertes Research analyst Irwin Lazar. That often means dealing with security settings that try to block new software, plus installing updates to the software over time. Google includes its own VP8 video codec free in the Chrome browser, but Microsoft, Apple and Mozilla have steered clear of VP8, Lazar said. H.264 is the standard that can get browser users connected to other videoconferencing platforms, he said.


Cisco wants to clear a path to getting H.264 included in WebRTC, a set of multimedia features in the HTML5 standard. The Internet Engineering Task Force is scheduled to choose a video codec for WebRTC at a meeting next week in Vancouver, British Columbia.


Stephen Lawson covers mobile, storage and networking technologies for The IDG News Service. Follow Stephen on Twitter at @sdlawsonmedia. Stephen's e-mail address is stephen_lawson@idg.com




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Cloud Management Platform ServiceMesh Acquired By CSC, A Consulting And IT Services Company


Cloud management company ServiceMesh has been acquired by CSC, which has in recent years emerged as an IT management outfit that focuses on helping companies move their apps to service providers. Terms of the deal were not disclosed.


ServiceMesh describes itself as an enterprise cloud management company that offers Global 2000 companies what it calls “IT as Service,” that charges on a pay as you go basis. It helps companies extend their data centers to public cloud services with all of the governance requirements that comes with managing an enterprise operation.


The ServiceMesh Agility Platform helps enterprise customers with self-service provisioning and management of standardized and fully governed Infrastructure as a Service, platform as a service and software as a service offerings. The company allows business to go fast, build new applications and manage multiple providers, all in a way that’s compliant.


The company had $15 million in funding from Ignition Partners. Frank Artale, a partner at Ignition, was a member of the ServiceMesh board of directors. It was ServiceMesh’s only round of institutional funding.


In a prepared release, CSC stated that the deal will enable the company to expand the reach of its BizCloud service, as well as allow it to present stronger competition against dominant cloud players like AWS.



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Rachel Zoe: Skyler Is Excited About a Sibling – Sometimes

"I think it's always a bit easier mentally the second time. The first time, everything is the unknown. My foot's tingling. What does that mean? Emergency!"Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/Vy6O1AskPFA/
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Deal of the Day: Krusell Donso Mobile UnderCover for iPhone 5S

Today Only: Purchase the Krusell Donso Mobile UnderCover for iPhone 5S and save 48%

The Krusell Donso Mobile UnderCover brings exclusivity and fashion to your iPhone 5S by combining a hard polycarbonate shell and a nice finish of genuine leather on the back for a smooth, professional look. Perfect to slide in and out of your pocket, this case is a great solution for style and protection all in one.

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Research points to potential window for treating CMV and preventing mother-to-child transmission

Research points to potential window for treating CMV and preventing mother-to-child transmission


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University of Massachusetts Medical School



UMass Medical School study shows that human cytomegalovirus rapidly evolves as it spreads from mother to fetus, and from organ to organ, providing genetic targets for new therapeutics



WORCESTER, MA New insights into how human cytomegalovirus (CMV), the leading cause of birth defects associated with infection spreads from pregnant mother to fetus and from organ to organ in newborns provides translational researchers an exciting new avenue for investigation that may lead to the development of therapeutic interventions. Using next generation sequencing and population genetic modeling, scientists at the University of Massachusetts Medical School (UMMS) and the Ecole Polytechnique Fdrale de Lausanne (EPFL) have found that CMV evolves rapidly and dramatically in humans. These findings, published in PLoS Genetics, provide new genetic targets that could impede the evolution of CMV and prevent its spread.


"These findings have important implications for how we think about and develop new therapeutic treatments for CMV," said Timothy F. Kowalik, PhD, associate professor of microbiology and physiological systems and senior author of the study. "Although CMV is able to infect a wide variety of organs throughout the body, there are a substantial number of genetic changes that occur before the virus can spread and replicate efficiently in different anatomic niches. If these genetic changes can be prevented, it may be possible to isolate and block the spread of CMV."


CMV is a ubiquitous virus that infects most of the human population and can move throughout the body from organ to organ. Infection is usually asymptomatic in healthy hosts, but may cause severe symptoms for patients with a compromised immune system, such as organ transplant recipients, HIV-infected persons, newborn infants or the fetus during gestation.


Congenital CMV infection, which is passed from a pregnant mother to fetus, is a significant cause of birth defects, and remains a high priority for vaccine development according to the nonprofit, Institute of Medicine. An estimated 30,000 infants per year in the U.S. are diagnosed with congenital CMV infection, and nearly 20 percent exhibit permanent neurologic effects such as hearing loss or developmental delay.


To better understand how CMV evolves in fetuses and newborns during symptomatic congenital infection, researchers at UMMS and the University of Minnesota Medical School collected samples from the plasma and urine of five congenitally infected infants during the first year after birth. Using next generation DNA sequencing, Kowalik and colleagues studied the diversity and changes in viral DNA sequences over time and between organs. Though the DNA sequences from viruses taken from the same type of sample (e.g. plasma) were similar to each other, the study's authors found dramatic differences between the sequences collected from viruses in the plasma and urine of the same infant. Surprisingly, the plasma and urine sequences from the same infant were as different as sequences from two unrelated infants.


These results suggest that CMV is able to evolve very quickly as the differences between the plasma and urine sequences likely occurred in the short period between the initial, in utero infection, and the first year after birth. However, the mechanism driving this phenomenon remained unclear.


To answer this question, researchers used mathematical modeling and statistical inference to uncover evidence that population bottlenecks and expansions may play a significant role in the virus' evolution after infection. Characterized by a substantial reduction in viral copies followed by a quick rebound, population bottlenecks and expansions can lead to dramatic changes in DNA sequences that result in two related populations quickly becoming dissimilar. In the case of CMV infection, this phenomenon appeared to coincide with the virus moving from the mother to the fetus and later migrating from the plasma to the kidneys.


The model also suggests that the timing of initial fetal infection in the patients was at 13 to 18 weeks gestational age, while viral spread from blood plasma to the kidneys occurred about 11 weeks later. "This timing," said Kowalik, "may provide an important window for treating CMV when it is most vulnerable and before it can evolve and spread."


Additional study showed that natural selection, the process through which certain advantageous biological traits become more common, results in as much as 20 percent of the viral genes changing as it moved from one biological niche to another. "Not surprisingly, the genes impacted by this selection process affect several viral functions involved in dissemination, including viral replication in distinct cell types and evasion of the host immune response, and are required to allow the virus to move to and replicate efficiently in different organs," said lead author of the study, Nicholas Renzette, PhD, a postdoctoral fellow at UMMS.


This new understanding of how CMV adapts and evolves after infection provides researchers with potential targets for treating the disease, said Kowalik. "This work shows that CMV infection spreads during a relatively small window during gestation, suggesting an opportunity for preventative treatments," he said. "Furthermore, the delay between initial fetal infection and dissemination to the kidneys, may present a window for stopping spread of the virus throughout the body, thereby preventing symptoms of infection, such as hearing loss."


The next step for Renzette, Kowalik and colleagues is to determine which genetic changes associated with immune responses to infection may be amendable to potential treatments.


###

About the University of Massachusetts Medical School

The University of Massachusetts Medical School (UMMS), one of five campuses of the University system, is comprised of the School of Medicine, the Graduate School of Biomedical Sciences, the Graduate School of Nursing, a thriving research enterprise and an innovative public service initiative, Commonwealth Medicine. Its mission is to advance the health of the people of the Commonwealth through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. In doing so, it has built a reputation as a world-class research institution and as a leader in primary care education. The Medical School attracts more than $240 million annually in research funding, placing it among the top 50 medical schools in the nation. In 2006, UMMS's Craig C. Mello, PhD, Howard Hughes Medical Institute Investigator and the Blais University Chair in Molecular Medicine, was awarded the Nobel Prize in Physiology or Medicine, along with colleague Andrew Z. Fire, PhD, of Stanford University, for their discoveries related to RNA interference (RNAi). The 2013 opening of the Albert Sherman Center ushered in a new era of biomedical research and education on campus. Designed to maximize collaboration across fields, the Sherman Center is home to scientists pursuing novel research in emerging scientific fields with the goal of translating new discoveries into innovative therapies for human diseases.


###


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Research points to potential window for treating CMV and preventing mother-to-child transmission


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

30-Oct-2013



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Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School



UMass Medical School study shows that human cytomegalovirus rapidly evolves as it spreads from mother to fetus, and from organ to organ, providing genetic targets for new therapeutics



WORCESTER, MA New insights into how human cytomegalovirus (CMV), the leading cause of birth defects associated with infection spreads from pregnant mother to fetus and from organ to organ in newborns provides translational researchers an exciting new avenue for investigation that may lead to the development of therapeutic interventions. Using next generation sequencing and population genetic modeling, scientists at the University of Massachusetts Medical School (UMMS) and the Ecole Polytechnique Fdrale de Lausanne (EPFL) have found that CMV evolves rapidly and dramatically in humans. These findings, published in PLoS Genetics, provide new genetic targets that could impede the evolution of CMV and prevent its spread.


"These findings have important implications for how we think about and develop new therapeutic treatments for CMV," said Timothy F. Kowalik, PhD, associate professor of microbiology and physiological systems and senior author of the study. "Although CMV is able to infect a wide variety of organs throughout the body, there are a substantial number of genetic changes that occur before the virus can spread and replicate efficiently in different anatomic niches. If these genetic changes can be prevented, it may be possible to isolate and block the spread of CMV."


CMV is a ubiquitous virus that infects most of the human population and can move throughout the body from organ to organ. Infection is usually asymptomatic in healthy hosts, but may cause severe symptoms for patients with a compromised immune system, such as organ transplant recipients, HIV-infected persons, newborn infants or the fetus during gestation.


Congenital CMV infection, which is passed from a pregnant mother to fetus, is a significant cause of birth defects, and remains a high priority for vaccine development according to the nonprofit, Institute of Medicine. An estimated 30,000 infants per year in the U.S. are diagnosed with congenital CMV infection, and nearly 20 percent exhibit permanent neurologic effects such as hearing loss or developmental delay.


To better understand how CMV evolves in fetuses and newborns during symptomatic congenital infection, researchers at UMMS and the University of Minnesota Medical School collected samples from the plasma and urine of five congenitally infected infants during the first year after birth. Using next generation DNA sequencing, Kowalik and colleagues studied the diversity and changes in viral DNA sequences over time and between organs. Though the DNA sequences from viruses taken from the same type of sample (e.g. plasma) were similar to each other, the study's authors found dramatic differences between the sequences collected from viruses in the plasma and urine of the same infant. Surprisingly, the plasma and urine sequences from the same infant were as different as sequences from two unrelated infants.


These results suggest that CMV is able to evolve very quickly as the differences between the plasma and urine sequences likely occurred in the short period between the initial, in utero infection, and the first year after birth. However, the mechanism driving this phenomenon remained unclear.


To answer this question, researchers used mathematical modeling and statistical inference to uncover evidence that population bottlenecks and expansions may play a significant role in the virus' evolution after infection. Characterized by a substantial reduction in viral copies followed by a quick rebound, population bottlenecks and expansions can lead to dramatic changes in DNA sequences that result in two related populations quickly becoming dissimilar. In the case of CMV infection, this phenomenon appeared to coincide with the virus moving from the mother to the fetus and later migrating from the plasma to the kidneys.


The model also suggests that the timing of initial fetal infection in the patients was at 13 to 18 weeks gestational age, while viral spread from blood plasma to the kidneys occurred about 11 weeks later. "This timing," said Kowalik, "may provide an important window for treating CMV when it is most vulnerable and before it can evolve and spread."


Additional study showed that natural selection, the process through which certain advantageous biological traits become more common, results in as much as 20 percent of the viral genes changing as it moved from one biological niche to another. "Not surprisingly, the genes impacted by this selection process affect several viral functions involved in dissemination, including viral replication in distinct cell types and evasion of the host immune response, and are required to allow the virus to move to and replicate efficiently in different organs," said lead author of the study, Nicholas Renzette, PhD, a postdoctoral fellow at UMMS.


This new understanding of how CMV adapts and evolves after infection provides researchers with potential targets for treating the disease, said Kowalik. "This work shows that CMV infection spreads during a relatively small window during gestation, suggesting an opportunity for preventative treatments," he said. "Furthermore, the delay between initial fetal infection and dissemination to the kidneys, may present a window for stopping spread of the virus throughout the body, thereby preventing symptoms of infection, such as hearing loss."


The next step for Renzette, Kowalik and colleagues is to determine which genetic changes associated with immune responses to infection may be amendable to potential treatments.


###

About the University of Massachusetts Medical School

The University of Massachusetts Medical School (UMMS), one of five campuses of the University system, is comprised of the School of Medicine, the Graduate School of Biomedical Sciences, the Graduate School of Nursing, a thriving research enterprise and an innovative public service initiative, Commonwealth Medicine. Its mission is to advance the health of the people of the Commonwealth through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. In doing so, it has built a reputation as a world-class research institution and as a leader in primary care education. The Medical School attracts more than $240 million annually in research funding, placing it among the top 50 medical schools in the nation. In 2006, UMMS's Craig C. Mello, PhD, Howard Hughes Medical Institute Investigator and the Blais University Chair in Molecular Medicine, was awarded the Nobel Prize in Physiology or Medicine, along with colleague Andrew Z. Fire, PhD, of Stanford University, for their discoveries related to RNA interference (RNAi). The 2013 opening of the Albert Sherman Center ushered in a new era of biomedical research and education on campus. Designed to maximize collaboration across fields, the Sherman Center is home to scientists pursuing novel research in emerging scientific fields with the goal of translating new discoveries into innovative therapies for human diseases.


###


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/uomm-rpt103013.php
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